DRviaSPCN: Drug Repurposing in Cancer via a Subpathway Crosstalk Network

A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.

Version:	0.1.5
Depends:	R (≥ 3.6)
Imports:	GSVA, clusterProfiler, graphics, igraph, pheatmap, stats
Suggests:	rmarkdown, knitr, DT
Published:	2025-01-09
DOI:	10.32614/CRAN.package.DRviaSPCN
Author:	Junwei Han [aut, cre, cph], Jiashuo Wu [aut]
Maintainer:	Junwei Han <hanjunwei1981 at 163.com>
License:	GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation:	no
CRAN checks:	DRviaSPCN results

Documentation:

Reference manual:	DRviaSPCN.html , DRviaSPCN.pdf
Vignettes:	DRviaSPCN (source, R code)

Downloads:

Package source:	DRviaSPCN_0.1.5.tar.gz
Windows binaries:	r-devel: DRviaSPCN_0.1.5.zip, r-release: DRviaSPCN_0.1.5.zip, r-oldrel: DRviaSPCN_0.1.5.zip
macOS binaries:	r-release (arm64): DRviaSPCN_0.1.5.tgz, r-oldrel (arm64): DRviaSPCN_0.1.5.tgz, r-release (x86_64): DRviaSPCN_0.1.5.tgz, r-oldrel (x86_64): DRviaSPCN_0.1.5.tgz
Old sources:	DRviaSPCN archive

Linking:

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